Benadryl Allergy Plus Congestion: What to Know

This medication may provide temporary relief from symptoms caused by hay fever and other upper respiratory allergies, including:

• Runny nose
• Sneezing
• Itchy or watery eyes
• Itching of the nose or throat
• Nasal congestion
• Sinus congestion or pressure

It can also temporarily relieve a runny nose, sneezing, and nasal congestion associated with the common cold.

The tablet formulation is labeled for adults and children ages 12 and older. For children younger than 12, check the product label or ask a doctor before use.

Children's Benadryl Allergy Plus Congestion liquid is labeled for children ages 6 to 11. Children ages 4 to 5 should only use it if directed by a doctor, and it should not be used in children younger than 4.

During an allergic reaction, the body releases histamine. Histamine contributes to symptoms such as sneezing, a runny nose, and itchy or watery eyes. Diphenhydramine blocks the effects of histamine, helping reduce these symptoms.

Diphenhydramine is a first-generation antihistamine and commonly causes drowsiness.

Phenylephrine is a decongestant. It causes blood vessels in the nasal passages to narrow, which is intended to reduce swelling and congestion.

However, the FDA has proposed removing oral phenylephrine from the over-the-counter monograph because available evidence does not show that it is effective as an oral nasal decongestant. This proposal is related to effectiveness, not a new safety concern.

Do not use Benadryl Allergy Plus Congestion if you are allergic to diphenhydramine, phenylephrine, or any other ingredient in the product.

Do not take it with another medication containing diphenhydramine, including some topical diphenhydramine products. You should also check the labels of other cold, allergy, and sinus medicines to avoid taking more than one antihistamine or decongestant.

Do not use this medication if you are currently taking a prescription monoamine oxidase inhibitor (MAOI), or if you stopped taking an MAOI within the past 2 weeks.

Ask a doctor before use if you have:

• Heart disease
• High blood pressure
• Thyroid disease
• Diabetes
• Glaucoma
• Trouble urinating because of an enlarged prostate
• A breathing problem such as emphysema or chronic bronchitis

Ask a doctor or pharmacist before taking it if you use sedatives or tranquilizers. If you are pregnant or breastfeeding, talk with a healthcare professional before use.

Diphenhydramine can cause significant drowsiness. Avoid alcoholic drinks while taking it because alcohol can increase drowsiness. Sedatives and tranquilizers can also increase this effect.

Use caution when driving, operating machinery, or doing anything that requires you to stay alert.

Other possible effects can include:

• Dry mouth
• Dizziness
• Nervousness
• Restlessness
• Difficulty sleeping

Some children may become excitable rather than sleepy after taking diphenhydramine.

Stop taking the medication and talk with a doctor if you develop nervousness, dizziness, or sleeplessness. You should also contact a healthcare professional if your symptoms do not improve within 7 days or occur with a fever.

Do not use diphenhydramine to make a child sleepy.